| 1912 |
Founded in 1912 as Nagahama Paper Box Shop. |
| 1921 |
Founded the Otsuka Group. Tetsuzaburo Otsuka established the Otsuka Pharmaceutical Division in Naruto, Tokushima Prefecture. Started as a chemical raw material manufacturer producing magnesium carbonate from nigari with 10 employees. |
| 1939 |
Renamed to Otsuka Pharmaceutical Factory. |
| 1940 |
Renamed to Otsuka Pharmaceutical Factory in 1940. |
| 1946 |
Entered the clinical nutrition field with infusion (drip injection). |
| 1950 |
Transferred the chemical raw material division to Otsuka Chemical Co., Ltd. |
| 1953 |
Started OTC pharmaceutical business with the launch of 'Oroamin Ointment'. |
| 1961 |
Established Otsuka Pharmaceutical Co., Ltd. |
| 1964 |
Major subsidiaries including Otsuka Pharmaceutical, Otsuka Food, and Otsuka Chemical were established. |
| 1964 |
Established Otsuka Pharmaceutical Co., Ltd., Otsuka Food Co., Ltd., Otsuka Chemical Co., Ltd., and others. |
| 1965 |
Launched 'Oroamin C'. |
| 1968 |
Launched household disinfectant 'Oroamin Ointment'. |
| 1968 |
Launched retort curry 'Bon Curry'. |
| 1969 |
Launched carbonated tonic drink 'Oroamin C'. |
| 1970 |
Founded as Union Giken in 1970, later renamed Otsuka Electronics. |
| 1970 |
Launched 'Gokiburi Hoi Hoi'. |
| 1971 |
In 1971, after filing a patent application for the first carbostyril core compound (Mikelan), launched a second product within ten years, transforming into a new drug manufacturer. |
| 1971 |
In 1971, participated in a supplement manufacturer born in California, USA, and its 'Nature Made' grew to become the No.1 vitamin supplement brand in the US. |
| 1971 |
Launched carbonated beverage 'Oroamin C'. |
| 1973 |
In 1973, started developing a sweat beverage inspired by Akihiko Otsuka, leveraging strengths in domestic infusion business to promote hydration and electrolyte replenishment in daily life. |
| 1973 |
Launched isotonic drink 'Pocari Sweat'. |
| 1974 |
Launched anti-malignant tumor agent 'Futrafur'. |
| 1974 |
Launched antibiotic intermediate 'GCLE'. |
| 1978 |
Renamed to Otsuka Packaging Industry Co., Ltd. in 1978. |
| 1979 |
In 1979, the Food Division of Toa Pharmaceutical was spun off and established, developing beverages such as Pocari Sweat and Demisoda for Korea. |
| 1979 |
Invested in Korea's Toa Foods (now Toa Otsuka Co., Ltd.). |
| 1980 |
Launched antipsychotic drug 'ABILIFY' in the US. |
| 1984 |
In 1984, developed and launched Aminoreban, an oral nutritional agent for hepatic encephalopathy, recognized as effective as an injection. |
| 1985 |
Established Otsuka America Inc. in the US. |
| 1986 |
Otsuka Pharmaceutical Co., Ltd. invested in Ridge Vineyards Inc., a renowned winery in California, USA. |
| 1986 |
Invested in Ridge Vineyards Inc. in California, USA. |
| 1989 |
Manufactures and sells hydrogen water with water hydrogen. Otsuka Chemical Co., Ltd. became its first overseas manufacturing and sales base. The company later expanded overseas, including a capital participation in Hebron in Spain in 1989. |
| 1990 |
Recognized for indications for gastritis, becoming a top brand of protective agents. |
| 1990 |
Launched gastric ulcer treatment 'Mucosta Tablets'. |
| 1991 |
In Japan, in 1991, began sales to enhance added value through Otsuka Food Co., Ltd. |
| 1994 |
Imported and sold Crystal Geyser Alpine Spring Water manufactured at CG Roxane LLC and Shasta Factory by Otsuka Beverage Co., Ltd. (now Otsuka Food Co., Ltd.) in Japan. |
| 1994 |
Invested in Crystal Geyser Water Company in the US. |
| 1995 |
In 1995, Pocari Sweat made a significant leap as a domestic beverage, establishing its position in the Japanese market. |
| 1995 |
Launched 'Pocari Sweat' in Hong Kong and Taiwan. |
| 1996 |
In 1996, the dietary fiber beverage 'Five Mini' was certified as a specified health food. |
| 1996 |
Launched dietary fiber beverage 'Five Mini'. |
| 1998 |
Major European mineral water business established in 1998, manufacturing and selling top French brand 'Cristalline' among others. Both companies are expanding their water business with a focus on the 'Water Century.' |
| 1998 |
Renamed the 1998 product 'Mannan Komachi'. |
| 1998 |
Launched 'Nature Made' in Japan. |
| 2002 |
Launched antipsychotic drug 'Eli Lilly' in the US. |
| 2005 |
In 2005, JIMRO Co., Ltd. changed its company name and became part of Otsuka Medical Devices Co., Ltd. |
| 2005 |
Suitable for patients with mild to moderate dehydration to replenish water and electrolytes. Launched nationwide in 2005. |
| 2005-06 |
This combination therapy was included in the 'Colorectal Cancer Treatment Guidelines' in June 2005 as an oral treatment within standardized chemotherapy. |
| 2006 |
In 2006, US Ridge Vineyards Inc. wine won the 'Paris Showdown' against French wines and was rated as the world's best. |
| 2008 |
Established Otsuka Holdings. |
| 2010 |
Recognized for efficacy against gastric cancer through the Ministry of Health, Labour and Welfare's priority review, becoming a standard treatment for advanced and recurrent gastric cancer from 2010. |
| 2010 |
Listed on the First Section of the Tokyo Stock Exchange. |
| 2011 |
Launched the carbonated tonic drink 'Oronamin C'. Achieved a total sales of 30 billion bottles by 2011. |
| 2011-09-05 |
On September 5, 2011, celebrated the 90th anniversary of the Otsuka Group at the Otsuka International Museum. |
| 2012 |
Launched in 2012 as a health food 'Wise Man's Meal Double Support' that suppresses absorption of sugar and fats. |
| 2013 |
In 2013, established Sukusuku Nursery School in Tsukuba by Daiho Pharmaceutical. |
| 2013 |
In 2013, established Sukusuku Nursery School in Tsukuba by Daiho Pharmaceutical. |
| 2014 |
In 2014, opened Bean Stalk Nursery School Osaka. |
| 2014 |
In 2014, opened Bean Stalk Nursery School Osaka. |
| 2015 |
Implemented ID warehouse and logistics system, optimizing work plans based on past data and algorithms. Introduced ID transportation in 2015. |
| 2016 |
Won the Otsuka Warehouse Logistics Award, achieving consecutive wins in 2016. |
| 2021-09 |
Celebrated the 100th anniversary of the Otsuka Group. |
