| 1912年 |
飼料製造のために、野村達次が浅草で購入したタイプの石鹸製造機。写真は1912年当時、実際に石鹸を製造している現場の様子。 |
| 1945年 |
Tatsuji graduated from the School of Science of Keio University. |
| 1947年 |
野村達次の母増子と姉美智子が神奈川県大磯町の野村邸でマウスの飼育開始 |
| 1947年 |
Tatsuji Nomura’s mother Masuko and sister Michiko started to rear mice as laboratory animals in their house. |
| 1951年 |
Kyoji Ando and Yoshio Tajima established the Experimental Animal Research Association. |
| 1951年 |
The two doctors soon established the Experimental Animal Research Association. |
| 1952年 |
野村増子と美智子がスナネズミの実験動物化に成功 |
| 1952年 |
1952年に実中研を創立 |
| 1952年 |
1952年の設立 |
| 1952年 |
The Central Laboratory for Experimental Animals (CLEA) was established in Nishitama, Tokyo. Masuko and Michiko Nomura succeeded in establishing the Mongolian Gerbil as a laboratory animal. |
| 1952年 |
Built within Ryozo’s farmland in 1952, CLEA took over the work of breeding mice that had so far been done by the Nomura family in Oiso. |
| 1952年 |
Since its establishment in 1952, CIEA has contributed substantially to the development of laboratory animal science in Japan by establishing techniques for breeding laboratory animals and conducting research on animal quality control. |
| 1953年 |
Silver Hamsters that the Nomura family had raised with utmost care all died at CLEA, due to the inexperienced breeding skill of the laboratory staff. |
| 1954年 |
固形飼料の供給開始 |
| 1954年 |
安東研究室を離れた達次は一人の実験動物生産業者となり、実中研が作り出したマウスを売り歩くことになる。 |
| 1954年 |
Supply of pelleted diet started. |
| 1954年 |
Tatsuji Nomura gave up his medical research and became an experimental animal breeder in 1954. |
| 1954年 |
Tatsuji decided to become a laboratory animal breeder. |
| 1955年 |
1955年に年間6万匹のマウスと12トンの固形飼料、当時の為替レートで720万円にものぼる大量発注をしてくれる。 |
| 1955年 |
US facility requested CLEA to supply 60,000 mice and 12 tons of diet on an annual basis. |
| 1956年 |
米軍第406医学総合研究所と契約締結 : 年間供給量：マウス60,000匹、固形飼料12,000kg |
| 1956年 |
Contract commenced with the US Military 406 Medical General Laboratory to supply 60,000 mice and 12,000 kg of diet annually. |
| 1957年 |
文部省直管財団法人として認可 : 米軍上記研究所が契約打ち切り : サルモネラ症大発生 |
| 1957年 |
The Central Laboratory for Experimental Animals was established as a nonprofit organization under the direct control of the Ministry of Education. |
| 1957年 |
Contract with the US Military discontinued. |
| 1957年 |
Major salmonellosis outbreak occurred. |
| 1957年 |
Thalidomide was a sleeping tablet released by a West German pharmaceutical company in 1957. |
| 1957年 |
CIEA was originally certified in 1957 as a foundation under the jurisdiction of the Ministry of Education. |
| 1957年08月 |
US Military abruptly terminated its contract. |
| 1957-08-06 |
実中研はついに文部省直管の財団法人となる。 |
| 1957-08-06 |
Central Laboratory of Experimental Animals becomes a formal foundation on August 6th, 1957 by appointing Dr. Koji Ando as its Representative Director, and Tatsuji Nomura as its Director. |
| 1957年10月 |
外部から持ち込まれたサルモネラ菌が瞬く間にマウス飼育舎に広がり、1958年10月に6,000匹、翌1959年9月にはさらに5,000匹のマウスを殺処分せざるを得なくなる。 |
| 1957年10月 |
salmonellosis germs brought in from elsewhere quickly spread among the CLEA mice. |
| 1958年 |
マウスの種親保持のため、達次の自宅に飼育舎建設 : 青山支所開設 |
| 1958年 |
パリで開かれた第一回国際実験動物会議に出席した安東博士は、SPF動物(Specific Pathogen-Free Animals)の本格的な生産が、米英連携で始まろうとしていることを知り、実中研でもSPF動物の実現と供給を目指そうと考える。 |
| 1958年 |
Rearing facilities constructed in grounds of Tatsuji Nomura’s house for maintenance of mouse breeding stock. |
| 1958年 |
Aoyama branch opened. |
| 1958年 |
In 1958, CLEA’s Dr. Ando attended the First International Conference on Experimental Animals in Paris. |
| 1958年 |
Thalidomide was first released in Japan in 1958. |
| 1958年10月 |
1958年10月に6,000匹のマウスを殺処分 |
| 1958年10月 |
the laboratory was forced to put down 6,000 mice in October, 1958. |
| 1959年 |
目黒支所開設 : 大泉支所（群馬県大泉町）開設 : サルモネラ症の根絶が不可能なため、西多摩郡瑞穂町の全コロニーを処分 同施設全廃・閉鎖 : 大泉支所の飼育施設焼失のため、ウィスター系ラットの生産中止 |
| 1959年 |
Meguro Branch opened. |
| 1959年 |
Oizumi Branch (Gunma Prefecture) opened. |
| 1959年 |
All colonies in Nishitama were disposed of as elimination of salmonellosis was impossible. |
| 1959年 |
The Nishitama facilities were closed and demolished. |
| 1959年 |
Production of Wistar strain rats was discontinued because of a fire in rearing facilities in the Oizumi Branch. |
| 1959年 |
NIH suggested to offer CLEA a total of 42.7 million yen assistance for four years, starting from 1959. |
| 1959年07月 |
1959年7月に群馬県大泉町に新しい飼育舎が建てられた。 |
| 1959年07月 |
a new breeding facility was constructed in Oizumi Town of Gunma Prefecture. |
| 1959年09月 |
1959年9月にはさらに5,000匹のマウスを殺処分せざるを得なくなる。 |
| 1959年09月 |
They then had to euthanize another 5,000 in September, 1959. |
| 1959年12月 |
1959年12月、今度は大泉町のラットの飼育舎一棟が火災で焼失する。 |
| 1959年12月 |
the rat breeding building was burnt to ashes by a fire. |
| 1960年 |
固形飼料の月産5トンだったのに対し、1960年には月産8トンを超すまでになっている。 |
| 1960年 |
固形飼料の販売収入が1957年に228万円だったのに対し、固形飼料は347万円あり、その後も固形飼料の販売収入が実験動物の販売収入を大きくリードする時代が続く。 |
| 1960年 |
1960年から1965年まで足掛け5年の歳月と1.9億円の資金を費やした新施設の建設プロジェクトが動き出す。 |
| 1960年 |
Grant received from the US National Institute of Health. |
| 1960年 |
the production and sales of CLEA’s original animal feed grew steadily, from a monthly supply of five tons in the beginning that came to exceed eight tons by 1960. |
| 1961年 |
目黒に最初のSPF動物施設完成 |
| 1961年 |
First Specific Pathogen-free (SPF) animal facility completed in Meguro. |
| 1961年06月 |
1961年6月、最初のSPF動物施設が目黒に完成する。 |
| 1961年06月 |
In June, 1961, the first SPF facility was completed in Meguro. |
| 1962年 |
川崎市野川にSPF動物生産施設完成 : SPFマウスの種親を米国より輸入 野川でSPFマウスの生産開始 |
| 1962年 |
1962年までに合計3,012万円の補助を受けられるようになる。 |
| 1962年 |
SPF animal production facilities completed in Nogawa, Kawasaki. |
| 1962年 |
SPF mouse breeding stock imported from the United States. |
| 1962年 |
SPF mouse production started in Nogawa. |
| 1962年 |
CLEA negotiated with the Science and Technology Agency to receive a total funding of 30.12 million yen up until 1962. |
| 1962年 |
CLEA issues an urgent order for 40 germfree mice to be imported from the US. |
| 1962年 |
AA Nude Mouse is a natural mutant with immune deficiencies. Discovered for the first time in 1962, this mouse is short-lived, undergrown and has a low reproduction capability as it has no thymus gland. |
| 1962年05月 |
1962年5月に川崎市野川に完成したSPF動物生産施設では、SPFマウスの生産と飼育を目指した。 |
| 1962年05月 |
The SPF animal production facility in Nogawa was established in May, 1962. |
| 1963年 |
1963年頃から、実中研の研究開発活動は一段と活発になる。 |
| 1963年 |
Supply of SPF mice started. |
| 1963年 |
Artificial nursing of rats achieved. |
| 1963年 |
R&D activities at CLEA started becoming very active from around 1963, when the production and sales of laboratory animals and pelleted diet finally went on track. |
| 1963年 |
The start of the full-fledged operation of the SPF animal production facility in Nogawa pushed up the production number of laboratory animals and pelleted diet. |
| 1963年 |
The supply number of mice reached 150,000 in 1963, 120,000 of rats, and 410 tons for pelleted diet. |
| 1963年 |
Thalidomide production was finally stopped in 1963. |
| 1964年 |
1964年の時点になっても8,180万円しか募金が集まらなかった。 |
| 1964年 |
CLEA turned to the Japanese business community and was able to receive a total of 81.8 million yen of contributions by 1964. |
| 1964年 |
Establishment of diet and environmental control and microbiologic testing methods for SPF animals. |
| 1964年 |
Production of 20,000 SPF mice a month achieved. |
| 1964年 |
Supply of SPF rats started. |
| 1964年 |
Managing Director Kyoji Ando receives the Medal of Honor with Purple Ribbon from the Japanese Government. |
| 1964年 |
Monthly production of diet reaches 60 tons. |
| 1964年 |
Consequently, the financial conditions of CLEA greatly improved, and the institution came to mark a 180 million yen profit by 1964. |
| 1964年 |
Out of the total, 140 million was churned out by its business-operating divisions, while the non-profit sectors marked a total profit of 36 million yen. In total, the surplus reached almost 7 million yen. |
| 1964年 |
The supply number of mice reached 250,000 in 1964, 150,000 of rats, and 543 tons for pelleted diet. |
| 1964年04月 |
1964年4月、厚生省は新薬の許認可申請を行う場合、適切な動物実験を行ったことを証明する資料の提示を義務付けた。 |
| 1964年04月 |
the Ministry of Health issued a notice of obligation to all pharmaceutical producers, requesting them to attach a document of proof on having conducted appropriate animal tests, whenever they applied for the approval and release of any new drug. |
| 1965年 |
Production/supply divisions separated to form the business entity, CLEA Japan Inc. |
| 1965年 |
Tatsuji Nomura is awarded the First Saburo Kojima Memorial Culture Prize. |
| 1965年 |
In contrast, no such problems occurred for rats that are around 10 times larger than mice. Hence their artificial nursing went smoothly, and CLEA had established their germfree breeding skill by 1965. |
| 1965年 |
Collaborative research with Armour Co. in the US (1965-1970). |
| 1965年02月 |
1965年2月に日本クレア社が設立される。 |
| 1965年02月 |
the business operating departments were separated from the activities of CLEA to form CLEA Japan Inc. |
| 1966年 |
1966年に医学研究部門を設立し、ヒトの医学発展に貢献する前臨床研究分野で様々な研究活動を展開するまでに発展する。 |
| 1966年 |
Reproduction and rearing of germfree animals achieved. |
| 1966年 |
Tatsuji Nomura becomes Director of CLEA. |
| 1966年 |
Medical Research Division established. |
| 1966年 |
Collaborative research with National Institute of Health (NIH) and Michigan University. |
| 1966年 |
Establishment of the Medical Research Department in 1966, CLEA started to aggressively exploit the pre-clinical research area that contributes to the medical research and treatment of humankind. |
| 1966年 |
establishment of the Medical Research Department in 1966 by inviting Dr. Tomoji Yanagita, a post graduate of the University of Michigan who had specialized in the areas of drug dependence and psychopharmacology, and was already world-renowned for developing a machine that could measure an animal’s “quest for drugs.” |
| 1967年 |
Name changed from CLEA to CIEA (Central Institute for Experimental Animals). |
| 1967年 |
Koji Ando, Director Emeritus, was awarded the Order of the Sacred Treasure, Gold Rays with Neck Ribbon. |
| 1967年 |
Research grant from the US Ford Foundation commenced (US$100,000 over 10 years). |
| 1968年 |
1968年に研究棟が野川に建設されると、医学研究部門は一層独立性の高い医学研究所となる。 |
| 1968年 |
The Medical Research Department became more independent with the construction of the research facility in Nogawa in 1968. |
| 1968年 |
In search of the cause and an effective cure, the Ministry of Health established Japan’s first special research unit on muscular dystrophy in 1968. |
| 1969年 |
1969年からは生殖生理学、薬理学、精神薬理学、病理毒性学、臨床薬理学の5部門で、研究活動に取り組むようになる。 |
| 1969年 |
1969年、無菌マウスと無菌ラット、およびノトバイオートの生産技術の開発に本格的に取りかかり |
| 1969年 |
International Council for Laboratory Animal Science (ICLAS) International Laboratory Animals Asian Pacific Meeting Secretariat established. |
| 1969年 |
Gnotobiotes Research Facilities completed in Nogawa, Kawasaki. |
| 1969年 |
CIEA chose to commit itself to the full-fledged development of germfree mice, germfree rats and gnotobiotes in 1969. |
| 1970年 |
1970年代に始まり、継続している。 |
| 1970年 |
Japan EDM Co. Ltd. established. |
| 1970年 |
Collaborative research with Ciba-Geigy in Switzerland. |
| 1970年 |
Collaborative research with Schering Plough in the US. |
| 1970年 |
Collaborative research with the World Health Organization (WHO). |
| 1970年 |
By 1970, CIEA established a system capable of a monthly steady production of 50 muscular dystrophy mice. |
| 1971年 |
1971年、野村達次がICLA日本代表に就任。 |
| 1971年 |
Tatsuji Nomura becomes Japan’s Representative in ICLAS. |
| 1972年 |
野村達次、日本癌学会評議員に就任 |
| 1972年 |
野村達次、ICLA財務理事に就任 |
| 1972年 |
田嶋嘉雄学術顧問、紫綬褒章授章 |
| 1972年 |
斎藤宗雄技術研究員、毎日工業技術奨励賞受賞 |
| 1972年 |
無菌マウスを月産300匹、ノトバイオートマウスを700匹、ノトバイオートラットも200匹ほど量産できる体制を確立 |
| 1972年 |
Tatsuji Nomura becomes a member of the ICLAS Board of Directors. |
| 1972年 |
Tatsuji Nomura becomes Treasurer of ICLAS. |
| 1972年 |
Yoshio Tajima, Technical Consultant is awarded the Medal of Honor with Purple Ribbon. |
| 1972年 |
Muneo Saito, Technical Researcher is awarded the Mainichi Industrial Technology Prize. |
| 1972年 |
In its second-term contract with the Ford Foundation that started from the autumn of 1972, CIEA planned to turn Japanese Monkeys into laboratory animals by constructing their colony away from humans and other animals. |
| 1972年 |
By 1972, it established a monthly production system of 300 germfree mice, 700 gnotobiote mice and 200 gnotobiote rats. |
| 1972年 |
By 1972, CIEA started to work on producing SPF muscular dystrophy mice. |
| 1972年09月 |
1972年秋からスタートした第二次契約ではニホンザルの実験動物化が予定され、鹿児島県奄美大島沖の枝手久島という無人島に人間や他の動物から隔離したコロニー建設することを計画した。 |
| 1973年 |
バイオサイエンス研究部門を設置 |
| 1973年 |
Biosciences Research Division established. |
| 1973年 |
CIEA started the planned mass production and breeding of Nude Mice from 1973. |
| 1973年 |
CIEA tried breeding the South American marmoset in 1973. |
| 1973年 |
17 wild marmosets died within a month after being brought over to Japan in 1973. |
| 1973-05-11 |
1973年になって紹介されたスナネズミの歴史（朝日新聞5月11日朝刊） |
| 1974年 |
川崎市野川に微生物棟完成 |
| 1974年 |
ナキウサギの実験動物化開始 |
| 1974年 |
Microbiology Building completed in Nogawa. |
| 1974年 |
Successful establishment of the rock rabbit as a laboratory animal. |
| 1974年 |
毎日工業技術奨励賞 |
| 1974年 |
CIEA comes to be awarded the Mainichi Industrial Technology Prize in 1974. |
| 1974年 |
By 1974, it established an annual production system of 300 such mice. |
| 1974年 |
CIEA has been expanding its R&D operations since 1974, when all of its departments were concentrated in Nogawa, Miyamae-ku, Kawasaki. |
| 1975年 |
G-CSF（Granulocyte Colony Stimulating Factor）は、ヒトがんの研究のためヌードマウスを研究開発していた過程で、患者がん組織を移植したヌードマウスから1975年に実中研が世界で初めて発見した白血球を増殖させる因子である。 |
| 1975年 |
All divisions are brought together in Nogawa with the completion of research facilities. |
| 1975年 |
Leukocytosis phenomenon observed in nude mice for the first time in the world. |
| 1975年 |
Tatsuji Nomura receives the highest merit award of the Japan Medical Association. |
| 1975年 |
Nude mouse production reaches 10,000. |
| 1975年 |
world’s first discovery of the G-CSF (Granulocyte Colony Stimulating Factor) by CIEA researchers. |
| 1975年 |
Referring to their crossbreed and pathogenic status, as well as their ease of handling, CIEA started trying to turn Gottingen Miniature Pigs into laboratory animals in 1975. |
| 1975年 |
By 1975, the annual production capacity of Nude Mice reached 15,000. |
| 1976年 |
The 2nd International Workshop on Nude Mice was held in Tokyo with Tatsuji Nomura as President. |
| 1976年 |
CIEA started researching the establishment of hybrid animals in 1976. |
| 1976年 |
By 1976, a full production cycle starting from the preparation of the breeding stock was established. |
| 1977年 |
Various voluntary research projects on small- to medium-sized monkeys were continued at CIEA even after the contract with the Ford Foundation ended in 1977. |
| 1977年 |
His Imperial Majesty Crown Prince Akihito (the current Heisei Emperor) visited the CIEA. |
| 1978年 |
文部省の補助を受けて日本初の実験動物のモニタリング検査を実施し1）遺伝的形質、2）微生物的品質、および3）モニタリングデータのコンピューター化の手法を模索した。 |
| 1978年 |
Hence in 1978, CIEA monitored the quality of laboratory animals by receiving funds from the Ministry of Education. |
| 1978年 |
In 1978, Dr. Akio Nomoto of the Tokyo Metropolitan Institute of Medical Science succeeded in establishing Japan’s first Polio Mouse. Approached by Dr. Nomoto, CIEA took over his research, and turned the Polio Mouse into an experimental animal. |
| 1979年 |
ICLAS（International Council for Laboratory Animal Science）は、1979年にグローバル・スタンダードの検査を行うモニタリングセンターを、世界各地に設置するべきだという勧告を発する。 |
| 1979年 |
The CIEA was designated as the ICLAS Monitoring Center. |
| 1979年 |
Accordingly, the International Council for Laboratory Animal Science (ICLAS) issued a notice in 1979 stating that a monitoring center conducting global standard checking should be established in each area around the world. |
| 1980年 |
By 1980, CIEA succeeded in turning the Gottingen Pigs into germfree animals. |
| 1981年 |
目標額2億円の新たな募金活動を1981年にスタートさせ |
| 1981年 |
The CIEA Support Group system started (34 companies). |
| 1981年 |
In response, CIEA started to raise funds in 1981 to collect a total of 200 million yen for building such a facility in Japan. |
| 1982年 |
勝木元也博士（慶應義塾大学医学部）を迎い入れて発生工学研究室（兼任）を新設 |
| 1982年 |
Developmental Engineering Research Laboratory established. |
| 1982年 |
By 1982, CIEA succeeded in turning the Gottingen Pigs into germfree animals, and formed a closed colony of over 120 Gottingen Pigs with a uniform genetic character. |
| 1983年 |
By 1983, CIEA succeeded in producing SPF muscular dystrophy mice. |
| 1984年 |
MCH（Multi-Cross Hybrid）マウスの量産を実現 |
| 1984年 |
Kosaburo Ezaki, Chief Investigator, received the Minister’s Prize of the Science and Technology Agency. |
| 1984年 |
Tatsuji Nomura was awarded the Medal of Honor with Purple Ribbon. |
| 1984年 |
After much trial and error CIEA succeeded in the volume production of Multi-Cross Hybrid (MCH) mice and MCH rats by 1984. |
| 1984年 |
In 1984, CIEA led the world again by turning the Rock Rabbit into an experimental animal. |
| 1985年 |
それらを日本クレア社から市販 |
| 1985年 |
Laboratory Animal Monitoring Building completed. |
| 1985年 |
CIEA started marketing them from CLEA Japan in 1985. |
| 1985年 |
CIEA also succeeded in the artificial breeding of the Volcano Rabbit, an endangered species, in 1985. By giving away a pair to the Jersey Foundation that works to protect and breed animals on the Red List, CIEA contributed to save the Volcano Rabbit that were once common animals found in the highlands of Mexico. |
| 1986年 |
世界初のICLASモニタリングセンターを構内に誕生 |
| 1986年 |
Establishment of the ICLAS Monitoring Center within the CIEA site. |
| 1986年 |
Meanwhile by 1986, CIEA established the world’s first ICLAS Monitoring Center within its laboratory grounds. |
| 1986年 |
The rasH2 Mouse is another mouse species that CIEA created in 1986, after about eight years of trial and error. |
| 1988年 |
1988年まで、マカクサル類の実験動物化の動きは停滞する。 |
| 1988年 |
artificial breeding of crab-eating Macaques were commenced in 1988 on an unmanned island in Indonesia. |
| 1988年 |
In 1988, CIEA led the world by successfully tracing the cause of this disease. |
| 1990年 |
アメリカのジョン•ミューア医学映画祭において「生命のプログラミングⅠ」が科学部門の金賞受賞 |
| 1990年 |
1990年に実中研と東海大学、国立がんセンターとの共同研究で開発されたrasH2マウス。 |
| 1991年 |
ポリオマウス実験動物化を開始 |
| 1991年 |
所史「六匹のマウスから」出版 |
| 1991年 |
中外製薬と共同研究してきたヌードマウスの白血球増多現象をもとに、白血球減少症治療薬のノイトロジンを世界市場に上市 |
| 1991年 |
From 1991 until around 1999, CIEA concentrated to develop the Polio Mouse. |
| 1992年 |
実験動物凍結保存施設完成 |
| 1993年 |
WHOがポリオマウスをポリオ根絶に活用することを決定 |
| 1993年 |
1993年から慶應義塾大学、国立医薬品食品衛生研究所と共同で発がん性試験のための実用化研究が開始された。 |
| 1993年 |
In 1993, the World Health Organization (WHO) conducted a comparative test on the Polio Mice and monkeys, to evaluate their efficacy on measuring the safety of the live Polio vaccine. |
| 1993-02-03 |
The feature article of CIEA’s Polio Mouse in the Nikkei newspaper issued on February 3, 1993. |
| 1995年 |
ICH世界大会においてrasH2マウスを発表 |
| 1995年 |
RasH2 mouse was announced at the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH. Contributed to the shortening of the period required and the simplification of evaluation of results of carcinogenicity test for new drugs. |
| 1997年 |
1997年から2001年に国際生命科学研究所（International Life Science Institute）と健康環境科学研究所（Health and Environmental Science Institute）の主導のもとに、日・米・EUの産官学50以上の施設が連携した検証試験が実施され、rasH2マウスは他の評価モデルよりも有用性の高いことが確認された。 |
| 1998年 |
In the autumn of 1998, CIEA joined hands with four experimental animal producing companies in Japan, the US and Europe, and signed a contract to regulate and standardize the quality of rats for laboratory use. |
| 2000年 |
Marmosets started to be actively used in the regenerative medical field from around 2000. |
| 2001年 |
US NPO Center for the Advancement of Health and Biosciences (CAHB) established. |
| 2002年 |
2002年 : 海外事業展開開始 : 『究極の免疫不全マウス』と評されるNOGマウスの作出 |
| 2002年 |
Overseas project development started. NOG mouse produced as “super immunodeficient mouse.” |
| 2005年 |
2005年 : NOGマウス特許取得 |
| 2005年 |
Patent granted for NOG mouse. |
| 2006年 |
2006年 : 野村達次所長、理事長に就任 : 「The 1st International Workshop on "Humanized Mice"」東京にて開催。会長：野村達次 |
| 2006年 |
Tatsuji Nomura becomes Director and Chairman of the CIEA Board. The 1st International Workshop on “Humanized Mice” was held in Tokyo with Tatsuji Nomura as President. |
| 2006年 |
NOG Mouse production by CIEA already reached 10,000 per year in 2006. |
| 2007年 |
Collaborative research on leukocytosis in nude mice with Chugai Pharmaceutical. Based on this phenomenon, lenograstim, a granulocyte colony-stimulating factor (brand name: Neutrogin) was marketed worldwide to treat leukopenia. |
| 2008年 |
In 2008, Kawasaki City approached us about relocating to an urban redevelopment district in Tonomachi, Kawasaki-ku. |
| 2010年 |
2010年 : 脊髄損傷や心筋梗塞の再生治療に直結するマーモセットの世界一のクローズド・コロニーを、日本クレア社で維持 |
| 2010年 |
World’s first closed colony of marmosets directly connected with regenerative treatment for spinal injuries and myocardial infarction maintained in the CLEA Japan Inc. |
| 2010年04月 |
construction began in April 2010. |
| 2011年 |
2011年 : 公益財団法人に認定 : 川崎市川崎区殿町に新研究所を開設 |
| 2011年 |
Authorized as a public interest incorporated foundation. New research facilities opened in Tonomachi, Kawasaki. |
| 2011年 |
The Central Institute for Experimental Animals (CIEA) certified as a public interest incorporated foundation. |
| 2011年 |
New laboratories opened in Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa. |
| 2011年 |
Designated as a Keihin Waterfront Area International Strategic Comprehensive Special Zone for Life Innovation. |
| 2011年03月 |
In March 2011, the City of Kawasaki officially launched an urban redevelopment project to build the Tonomachi 3-chome area in Kawasaki-ku, the former site of Isuzu Motors’ Kawasaki plant, into a world-leading R&D center in the health and medical fields, naming the area 'KING SKYFRONT'. |
| 2011-04-01 |
newly certified as a public interest incorporated foundation under the jurisdiction of the Prime Minister as of April 1, 2011. |
| 2011年07月 |
CIEA opened a new research establishment at the KING SKYFRONT. |
| 2011年07月 |
The new research establishment was completed in July 2011, three years after its conception, and a grand opening ceremony was held with concerned parties and local residents invited. |
| 2011年12月 |
in December 2011, the KING SKYFRONT area was designated as an 'International Strategic Special Zone'. |
| 2011-12-22 |
on December 22, 2011, the project was approved as the 'Keihin Waterfront Area International Strategic Comprehensive Special Zone for Life Innovation'. |
| 2012年 |
Japan Society for Marmoset Research established, and its Secretariat established at CIEA. |
| 2012年 |
Received “Conformity” rating by the Japan Health Science Foundation (HS) for external verification in animal care and use. |
| 2013年 |
2013年に開始された。実中研は第1回目から参加し... |
| 2013年 |
Tatsuji Nomura, Research Director and Chairman, passed away. |
| 2013年 |
Ryuta Nomura was appointed as Chairman. |
| 2013年 |
Junichi Hata appointed as Research Director. |
| 2013年 |
“KING SKYFRONT Summer Science Event” started. |
| 2013年 |
KING SKYFRONT Summer Science Event (Executive Committee Chairperson: Ryuta Nomura) is a hands-on event started in 2013 in which universities, research institutes, and companies operating at the KING SKYFRONT make use of their own business activities to introduce science and technology to elementary school students in a casual way. CIEA has participated in this event since the beginning, and has received a lot of positive feedback from elementary school students after planning events to familiarize them with science and technology , and CIEA considers it an important opportunity to make contact with many people. |
| 2013-01-11 |
2013年1月11日に、野村達次理事長・所長が逝去した。享年90歳であった |
| 2013-01-11 |
On January 11, 2013, Tatsuji Nomura, Research Director, and Chairman passed away at the age of 90. He served as director of CIEA since its founding in 1952, and also as its chairman since 2006. Throughout this period, he actively developed research and projects related to laboratory animals and animal experimentation, established the foundation of the concept of laboratory animals, and made significant contributions not only to laboratory animal science but also to other related research fields. His activities were not limited to Japan, but were global in scope, including serving as the Japanese representative to the US-Japan meetings on laboratory animal science and as an officer (Treasurer and Vice President) of the International Council for Laboratory Animal Science (ICLAS). He was awarded the Medal with Purple Ribbon in 1984, the Eiji Yoshikawa Cultural Prize in 1992, and designated a Person of Cultural Merit in 1997 in Japan. Overseas, he was also awarded the ICLAS Muehlenbeck Memorial Award in 1988, the U.S. Food and Drug Administration (FDA) Distinguished Alumni Award in 1998 and 2000, and the ICLAS Marie Coates Award in 2005. |
| 2013-01-11 |
Dr. Tatsuji Nomura sadly passed away on January 11, 2013. |
| 2014年 |
2014年に、母校である慶應義塾大学医学部の慶應医学会に「野村達次賞」が創設された |
| 2014年 |
Nomura Tatsuji Award established by the Keio Medical Society. |
| 2014年 |
In 2014, a year after the passing of Research Director and Chairman Tatsuji Nomura, the Keio Medical Society of his alma mater, Keio University School of Medicine, established the Nomura Tatsuji Award, which is a great honor for us as CIEA. |
| 2016年 |
2016年から実中研が主催している「実中研サイエンスキャンプ」開催 |
| 2016年 |
“CIEA Science Camp” (Sponsored by CIEA. Subsidized by Children’s Dream Fund) started. |
| 2016年 |
The 63rd Annual Meeting of the Japanese Association for Laboratory Animal Science held; President: Mamoru Ito. |
| 2016年 |
The camp has been hosted by CIEA since 2016 under the theme “Let’s learn about the process from the birth of life to the formation of the body.” This program aims to cultivate children’s understanding and interest in science through activities that familiarize them with science and science-related topics and is supported by the Children’s Dream Fund of the National Institution for Youth Education. The program is targeted at junior high school students, and the number of applicants always exceeds the limit, indicating the high level of need for the program. During the event, lectures are given on the birth of life and how the body is formed, while hands-on activities include DNA extraction experiments, observation of fertilized eggs in mice, and staining and observation of cells and tissues. Our program has been well accepted because it emphasizes hands-on activities for each participant, and we have devised textbooks, DVDs, and prepared slides that can be used as home study materials. |
| 2017年 |
2017年に新たにライブイメージングセンターを新設した |
| 2017年 |
A new Animal Live Imaging Center established. |
| 2017年 |
in 2017, it established a new Live Animal Imaging Center. |
| 2020年 |
Awarded the 3rd Japan Medical Research and Development Awards in the Minister of State for Health and Medical Care Strategies Prize. Mamoru Ito appointed as Research Director. |
| 2020-01-10 |
2020年1月10日に、第3回日本医療研究開発大賞 健康・医療戦略担当大臣賞を受賞した。 |
| 2020-01-10 |
On January 10, 2020, CIEA was awarded the Minister of State for Health and Medical Care Strategies Prize at the 3rd Japan Medical Research and Development Awards, for its “contribution to R&D in the medical field through the development of cutting‑edge laboratory animals.” |
| 2021年 |
2021年に医薬品規制調和国際会議(ICH: International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use)のガイドラインS1B 補遺(ICH S1B(R1))において、rasH2マウスが遺伝子改変マウスを用いたがん原性試験の世界標準動物として個別名称と具体的利用法が掲載された。 |
| 2021年 |
The rasH2 mouse is officially listed in the ICH S1B Guideline Addendum and recognized as a global standard system. |
| 2022-05-15 |
Publication of “From Six Mice, 3 — How to Create a World Standard System: the CIEA Way” by Ryuta Nomura. Celebrates its 70th anniversary on May 15. |
| 2023年 |
2023年 : 末松誠が所長に就任 |
| 2023年 |
Makoto Suematsu appointed as Research Director. |
| 2024年 |
2024年 : 公益財団法人実中研（英語名称：Central Institute for Experimental Medicine and Life Science）に法人名変更 |
| 2024年 |
Name changed from CIEA to CIEM (Central Institute for Experimental Medicine and Life Science). |
